This patented high‑performance probiotic strain was isolated and screened from traditional Chinese fermented foods in 2008 by researchers from the National Engineering Research Center for Functional Food, Jiangnan University.
The strain can survive in simulated gastric fluid at pH 2.5 and culture medium with 0.2% bile salt, demonstrating its capability to maintain high viability in the host’s intestinal tract. CN2018 exhibits strong inhibitory activity against Helicobacter pylori growth and can significantly reduce the activity of Helicobacter pylori urease.
In animal models of Helicobacter pylori infection, Lactiplantibacillus plantarum CN2018 markedly alleviated Helicobacter pylori infection in mice with reduced anti‑Helicobacter pylori IgG antibody levels. It interferes with Helicobacter pylori colonization, lowers Helicobacter pylori loads in gastric tissue , and prevents pathological changes in gastric tissue