Key Features
Isolated from vegetables, deposit number GDMCC No:61634. Lactobacillus plantarum CCFM1180 can inhibit the body‑weight growth rate and weight gain of ovariectomized mice. The weight gain of the model group was 10.83±2.025 g, while that of the Lactobacillus plantarum CCFM1180 group was 5.66±1.802 g.
It reduces serum total cholesterol (TC) in ovariectomized mice. Compared with the model group, the serum TC level of mice in the CCFM1180 intervention group decreased by 12.57%.
The IL‑6 level in mice of the CCFM1180 intervention group dropped by 68.53% relative to the model group. Lowering IL‑6 levels in adipose tissue helps alleviate obesity, diabetes, non‑alcoholic steatohepatitis and other disorders. It can elevate serum estradiol in ovariectomized mice: the serum estradiol of the CCFM1180 intervention group reached 17.54±1.836 ng/L versus 15.27±0.4353 ng/L in the model group. It up‑regulates the expression level of estrogen receptor (ER) in adipose tissue to relieve symptoms triggered by estrogen withdrawal. In addition, it increases fecal short‑chain fatty‑acid levels in mice, improves the health status of ovariectomized mice, and effectively modulates metabolism and mitigates obesity.